四碘甲状腺乙酸

生物活性体外研究体内研究四碘甲状腺乙酸试剂级价格

四碘甲状腺乙酸

CAS号:67-30-1
英文名:3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
中文名:四碘甲状腺乙酸
CBNumber:CB6124010
分子式:C14H8I4O4
分子量:747.83
MOL File:67-30-1.mol

四碘甲状腺乙酸化学性质

熔点 :219-220 °C (decomp)
沸点 :544.8±50.0 °C(Predicted)
密度 :2.727±0.06 g/cm3(Predicted)
储存条件 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度 :acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow)
形态 :powder to crystal
酸度系数(pKa) :3.98±0.10(Predicted)
颜色 :White to Yellow to Green
InChIKey :PPJYSSNKSXAVDB-UHFFFAOYSA-N

安全信息

危险品标志 :T+
危险类别码 :28
安全说明 :45
危险品运输编号 :UN 2811 6.1/PG 1
WGK Germany :3
RTECS号 :CY1585800
海关编码 :2916.39.7900

四碘甲状腺乙酸性质、用途与生产工艺

生物活性 Tetrac (Tetraiodothyroacetic acid)，L-甲状腺素 (T4) 的天然衍生物，是甲状腺素整合素受体拮抗剂。Tetrac 阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3) 在整联蛋白 αvβ3 上甲状腺激素的细胞表面受体处的作用。Tetra 具有抗血管生成和抗肿瘤活性。

体外研究

Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status.
Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells.
Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc , but promotes expression of CASP2 and THBS1 .

Cell Proliferation Assay

Cell Line:	HT-29 and HCT116 cells
Concentration:	0.01, 0.1, 1 μM
Incubation Time:	0, 2, 4, 6 days
Result:	Induced anti-proliferation of K-RAS wild-type colorectal cancer cells.

Western Blot Analysis

Cell Line:	HT-29 and HCT116 cells
Concentration:	0.1 μM
Incubation Time:	30 min
Result:	Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment.

体内研究

Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice.

Animal Model:	Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells
Dosage:	35 μg per day
Administration:	P.o. (added to the drinking water) daily for 40 days
Result:	Delayed the onset of ocular melanoma. Reduced the S-100 and integrin staining level in the B16F10 mice model.