(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸
- CAS号:176199-48-7
- 英文名:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
- 中文名:(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸
- CBNumber:CB61042715
- 分子式:C8H11NO4
- 分子量:185.18
- MOL File:176199-48-7.mol
- 熔点 :270-271 °C
- 沸点 :376.4±32.0 °C(Predicted)
- 密度 :1.569
- 储存条件 :Keep in dark place,Sealed in dry,2-8°C
- 溶解度 :H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
- 形态 :Powder
- 酸度系数(pKa) :2.06±0.40(Predicted)
- 颜色 :White to off-white
(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸性质、用途与生产工艺
- 生物活性 Eglumegad (LY354740) 是一种有效,选择性的 group II (mGlu2/3) receptor 激动剂,对人mGlu2和mGlu3受体的 IC50 分别为5和24 nM。
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靶点
mGluR2R
5 nM (IC 50 )
mGluR3R
24 nM (IC 50 )
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体外研究
Eglumegad (LY354740) down-regulates spots 1014, 1822 (hypoxia up-regulated protein 1), 4513 (an isoform of protein disulfide isomerase 3), 6204, 6312, 7306 (26S proteasome non-ATPase regulatory subunit 7) and protein spots 1013 and 6005 (destrin), and up-regulates spot 6507 (collapsin response mediator protein 1) in mouse cortical neurons.
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体内研究
Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 −/− or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 −/− and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 −/− mice. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC.
- 更新日期:2024/11/08
- 产品编号:HY-18941
- 产品名称:(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad
- CAS编号:176199-48-7
- 包装:5mg
- 价格:1500元
- 更新日期:2024/11/08
- 产品编号:HY-18941
- 产品名称:(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad
- CAS编号:176199-48-7
- 包装:10mM * 1mLin Water
- 价格:1650元
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6257
- 优势度:58