ChemicalBook CAS数据库列表 哌卡嗪
哌卡嗪
- CAS号:60-89-9
- 英文名:pecazine
- 中文名:哌卡嗪
- CBNumber:CB5876419
- 分子式:C19H22N2S
- 分子量:310.46
- MOL File:60-89-9.mol
哌卡嗪化学性质
- 熔点 :80°C
- 沸点 :bp4 230-235°
- 密度 :1.1252 (rough estimate)
- 折射率 :1.6270 (estimate)
- 储存条件 :Hygroscopic, Refrigerator, under inert atmosphere
- 溶解度 :DMSO : 130 mg/mL (418.73 mM; Need ultrasonic)
- 形态 :Oil
- 颜色 :Light yellow to light brown
- 水溶解性 :5.588mg/L(24 ºC)
哌卡嗪性质、用途与生产工艺
- 生物活性 Mepazine (Pecazine) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的 IC50 分别为 0.83 和 0.42 μM。Mepazine 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
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靶点
MALT1
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体外研究
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells.
Cell Viability Assay
Cell Line: ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration: 5, 10, and 20 μM Incubation Time: 4 days Result: Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells. -
体内研究
Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg null (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10.
Animal Model: 6- to 8-week-old female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage: 400 μg per animal (25 g), corresponding to approximately 16 mg/kg. Administration: Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result: Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
哌卡嗪上下游产品信息
上游原料
下游产品
哌卡嗪 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-121282
- 产品名称：Mepazine
- CAS编号：
- 包装：25 mg
- 价格：1150元
- 更新日期：2024/11/08
- 产品编号：HY-121282
- 产品名称：Mepazine
- CAS编号：
- 包装：50 mg
- 价格：1750元
哌卡嗪生产厂家
- 公司名称：VladaChem GmbH
- 联系电话：+49-7246-3082843
- 电子邮件：info@vladachem.de
- 国家：德国
- 产品数：1859
- 优势度：58
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