(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- CAS号:1000578-26-6
- 英文名:(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- 中文名:(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- CBNumber:CB5846829
- 分子式:C18H25N3
- 分子量:283.41
- MOL File:Mol file
- 沸点 :413.3±45.0 °C(Predicted)
- 密度 :1.09±0.1 g/cm3(Predicted)
- 储存条件 :Desiccate at -20°C
- 溶解度 :<28.34mg/ml in ethanol; <28.34mg/ml in DMSO
- 形态 :oil
- 酸度系数(pKa) :9.20±0.20(Predicted)
- 颜色 :Yellow
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN性质、用途与生产工艺
- 生物活性 AS19 是一种有效的选择性 5-HT7 受体激动剂，IC50 值为 0.83 nM，Ki 为 0.6 nM。AS19 对 5-HT7 的选择性高于 5-HT1A，5-HT1B，5-HT1D 和 5-HT5A 受体 (Kis 分别为 89.7 nM，490 nM，6.6 nM 和 98.5 nM)。AS19 可增强记忆力，并逆转由 Scopolamine 或 Dizocilpine 引起的健忘症。
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靶点
Human 5-HT 7 Receptor
0.83 nM (IC 50 )
Human 5-HT 7 Receptor
0.6 nM (Ki)
5-HT 1A Receptor
89.7 nM (Ki)
5-HT 1B Receptor
490 nM (Ki)
5-HT 1D Receptor
6.6 nM (Ki)
5-HT 5 Receptor
98.5 nM (Ki)
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体外研究
The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours.
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体内研究
AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task.
Animal Model: Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task Dosage: 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Subcutaneous injection; for 24 hours Result: Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task.
- 更新日期：2025/02/08
- 产品编号：HY-103142
- 产品名称：AS19
- CAS编号：1000578-26-6
- 包装：1 mg
- 价格：2320元
- 更新日期：2025/02/08
- 产品编号：HY-103142
- 产品名称：(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN AS19
- CAS编号：1000578-26-6
- 包装：5mg
- 价格：4700元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
