多肽YY(人)

简介生理作用生物活性靶点体外研究体内研究多肽YY(人) 试剂级价格

多肽YY(人)

CAS号:118997-30-1
英文名:PEPTIDE YY, HUMAN
中文名:多肽YY(人)
CBNumber:CB5758746
分子式:C194H295N55O57
分子量:4309.7524
MOL File:118997-30-1.mol

多肽YY(人)化学性质

储存条件 :−20°C
形态 :Solid
颜色 :White to off-white
水溶解性 :1mg/mL in water
序列 :H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

安全信息

WGK Germany :3

多肽YY(人)性质、用途与生产工艺

简介胃肠激素的基本结构是氨基酸组成的直链多肽，其功能 ( 生物学作用 )取决于所含的氨基酸，不同胃肠激素在相同顺序位置上的氨基酸相同的越多，则功能越接近。
生理作用
在不同生理状态下,血液循环中胃肠道激素水平的变化，可通过作用于外分泌腺、平滑肌、神经系统等组织，调节机体与能量代谢平衡相关的多种生理过程如血糖稳定、胃肠蠕动和食欲调控、脂肪细胞因子分泌等。
生物活性 Peptide YY (PYY) 是一种肠道激素，可调节食欲和抑制胰腺分泌。Peptide YY (PYY) 可以通过神经肽 Y 受体 (Neuropeptide Y receptors) 介导其作用。
靶点

Neuropeptide Y receptor
体外研究

The gut hormone peptide YY ( PYY) belongs to the pancreatic polypeptide (PP) family along with PP and neuropeptide Y (NPY). These peptides mediate their effects through the NPY receptors of which there are several subtypes (Y1, Y2, Y4, and Y5). Pancreatic polypeptide YY (Peptide YY), a small peptide consisting of 36 amino acids, is originally isolated from porcine intestine and is secreted from the neuroendocrine cells (L cells) in the mucosa of the gastrointestinal tract, but it has been localized to other locations associated with the digestive system.
体内研究

Peptide YY is capable of strongly inhibiting secretin-stimulated pancreatic secretion. A very low dose of Peptide YY (10-20 pmol/kg) significantly decreases the pancreatic secretion of bicarbonate as well as fluid that is stimulated by a single dose of secretin (0.1 unit/kg). A dose of Peptide YY of 100-200 pmol/kg causes a 70-80% reduction of the pancreatic bicarbonate and fluid secretion. Peptide YY is localised to blood vessels and atherosclerotic plaques of rabbits. It causes vasoconstriction of the vascular tree.
参考质量标准外观:白色粉末
纯度(HPLC) ≥97.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%