ANTI-CD28抗体
- CAS号:
- 英文名:Anti-CD28 Antibody
- 中文名:ANTI-CD28抗体
- CBNumber:CB55712444
- 分子式:
- 分子量:0
- MOL File:Mol file
ANTI-CD28抗体性质、用途与生产工艺
-
描述
小鼠单克隆抗体to CD28
- 宿主 Mouse
-
种属反应性
与反应: Human
- 免疫原 Stimulated human leucocytes.
-
偶联性
Unconjugated
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验证的应用
适用于: Flow Cyt, IHC-Fr
-
制备
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD28 (rh CD28; Catalog#11524-H08H; P10747-1; Met 1-Pro 152). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
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品牌示例
Immunocytochemistry/ Immunofluorescence - Anti-CD28 antibody [CB28] (ab193350)
Immunofluorescent staining of Jurkat cells using ab193350 followed by goat anti-Mouse IgG conjugated to CF488 (green). Red Dot is used to label nuclei (red).
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背景
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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