5-氨基尿苷

5-氨基尿苷化学性质

熔点 :214-216 °C
密度 :1.712±0.06 g/cm3(Predicted)
储存条件 :−20°C
酸度系数(pKa) :9.31±0.10(Predicted)
InChI :InChI=1S/C9H13N3O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2,10H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChIKey :YBTWWWIJBCCYNR-UAKXSSHOSA-N
SMILES :OC[C@H]1O[C@@H](N2C=C(N)C(=O)NC2=O)[C@H](O)[C@@H]1O

安全信息

5-氨基尿苷性质、用途与生产工艺

生物活性 5-Aminouridine 可以修饰核碱基并且可以掺入靶 DNA 中。5-Aminouridine 表现出广泛的生物活性，可抑制肿瘤，真菌和病毒的生长。
体外研究

This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy) ₃ ³⁺ . These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites.
体内研究

5-Aminouridine inhibits incorporation of carbamylaspartate into pyrimidines of both RNA and DNA in rat lived and [ ³² P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma.

5-氨基尿苷上下游产品信息

上游原料

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