LMT-28
- CAS号:1239600-18-0
- 英文名:LMT-28
- 中文名:LMT-28
- CBNumber:CB54670121
- 分子式:C17H29NO4
- 分子量:311.42
- MOL File:1239600-18-0.mol
- 沸点 :452.9±38.0 °C(Predicted)
- 密度 :1.065±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :100 mg/mL in DMSO (321.11 mM),
- 酸度系数(pKa) :13.97±0.20(Predicted)
- 形态 :oil
- 颜色 :colorless to light yellow, oil
- 水溶解性 :< 0.1 mg/mL Water (insoluble)
LMT-28性质、用途与生产工艺
- 生物活性 LMT-28 是一种具有口服活性的通过直接与 gp130 结合而发挥作用的 IL-6 抑制剂。LMT-28 具有低毒性，并选择性抑制 IL-6 诱导的 STAT3、JAK2 和 gp130 的磷酸化。
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靶点
IL-6
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体外研究
LMT-28 reduces IL-6-induced luciferase activity by ~90% at a concentration of 50 μM and exhibits an IC 50 value of 5.9 μM. LMT-28 (1-10 μM; 72 hours) inhibits IL-6-induced proliferation of the human erythroleukemic cell line TF-1.
LMT-28 (1-100 μM; 1 hour) selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130.Cell Proliferation Assay
Cell Line: TF-1 cells (1 ng/mL IL-6-induced) Concentration: 1, 10, 100, 1000, 10000 nM Incubation Time: 72 hours Result: Markedly inhibited IL-6–induced TF-1 proliferation with an IC50 value of 7.5 μM. Western Blot Analysis
Cell Line: HepG2 cells (treated with 10 ng/mL IL-6) Concentration: 1, 3, 10, 30, and 100 μM Incubation Time: 1 hour Result: Inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130. -
体内研究
LMT-28 (0-0.5 mg/kg; p.o.; once daily for 15 days) alleviates CIA in mice.
LMT-28 (0.25 or 1 mg/kg; p.o.) ameliorates the progression of pancreatitis in mice. LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex.Animal Model: Six-week-old male DBA/1J mice (collagen-induced arthritis mice, CIA) Dosage: 0-0.5 mg/kg Administration: Oral; once daily for 15 days Result: Markedly reduced the serum levels of cartilage oligomeric matrix protein (COMP) by 50%, serum amyloid P (SAP) by 55%, and anti-CII IgG by 62%.
- 更新日期：2024/11/08
- 产品编号：HY-102084
- 产品名称：LMT-28
- CAS编号：
- 包装：1 mg
- 价格：320元
- 更新日期：2024/11/08
- 产品编号：HY-102084
- 产品名称：LMT-28 LMT-28
- CAS编号：1239600-18-0
- 包装：5mg
- 价格：800元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52924
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
