内皮素2

概述作用生物活性体外研究体内研究内皮素2 试剂级价格

内皮素2

CAS号:123562-20-9
英文名:H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
中文名:内皮素2
CBNumber:CB5442638
分子式:C115H160N26O32S4
分子量:2546.92
MOL File:123562-20-9.mol

内皮素2化学性质

密度 :1.286±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
储存条件 :−20°C
溶解度 :Soluble to 1 mg/ml in DMSO
形态 :powder
颜色 :white
水溶解性 :Soluble in water (1 mg/ml)

安全信息

危险品标志 :T+
危险类别码 :26/27/28
安全说明 :28-36/37-45
危险品运输编号 :UN 2811 6.1/PG 1
WGK Germany :3
F :3-10
危险等级 :6.1

内皮素2性质、用途与生产工艺

概述内皮素具有内皮素1、内皮素2、内皮素3、和β-内皮素4种异形肽。体内分布十分广泛，在循环系统中静脉含量高于动脉，冠状动脉明显高于肺动脉；心房含量高于心室、心内膜高于心外膜；神经、消化、生殖等系统的组织中亦存在内皮素。内皮素的消除降解主要在肺、肾和血管平滑肌细胞，半衰期在1小时以上。
作用内皮素2被认为是如同CC趋化因子配体2(C-Cmotifchemokineligand2，CCL2)一样，是有效的炎症趋化因子，对中性粒细胞有低水平趋化作用，能够通过MAPK通路，由内皮素B受体介导在巨噬细胞的趋化作用。
生物活性 Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) 是由 21 个氨基酸组成的血管活性肽，可与 G 蛋白连接的跨膜受体，ET-RA 和 ET-RB 结合。
体外研究

At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC ₅₀ =0.52 nM).
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.
体内研究

Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr.