L-165041
- CAS号:79558-09-1
- 英文名:L-165,041
- 中文名:L-165041
- CBNumber:CB5422531
- 分子式:C22H26O7
- 分子量:402.44
- MOL File:79558-09-1.mol
- 熔点 :127-128 °C(lit.)
- 沸点 :600.8±55.0 °C(Predicted)
- 密度 :1.222±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: >10 mg/mL
- 形态 :solid
- 酸度系数(pKa) :3.23±0.10(Predicted)
- 颜色 :off-white
- 稳定性 :Light Sensitive
- WGK Germany :3
L-165041性质、用途与生产工艺
- 生物活性 L-165041 是一种细胞渗透的 PPARδ 激动剂，对 PPARδ 和 PPARγ 的 Ki 值分别为 6 nM 和 约 730 nM，可以在 NIH-PPARδ 细胞中诱导脂肪细胞分化。
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靶点
PPARδ
6 nM (Ki)
PPARγ
730 nM (Ki)
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体外研究
L-165041 is a PPARδ agonist, with K i s of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively. L-165041 (1 or 5 µM) inhibits VEGF-induced endothelial cells (ECs) proliferation and migration. L-165041 negatively affects cell cycle progression in VEGF-activated human umbilical vein ECs (HUVECs). L-165041 (10 µM)inhibits PPARδ-independent, VEGF-induced angiogenesis. PPARδ ligand L-165041 inhibits PDGF-induced rVSMC proliferation and migration. With 1 h of L-165041 pretreatment, PDGF-induced cellular migration is inhibited. L-165041 (10 μM) significantly suppresses S phase transition induced by PDGF.
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体内研究
L-165041 (5 mg/kg/day, i.p.) significantly lowers the formation of lipid droplets in mice. L-165041 markedly reduces the level of both the hepatic cholesterol and triglycerides in mice. L-165041 increases mRNA expression levels of PPARδ compared to the vehicle group. Lipoprotein lipase (LPL) expression in L-165041-treated mice is significantly higher than that in the vehicle group.
- 更新日期：2024/11/08
- 产品编号：HY-20019
- 产品名称：L-165041 L-165041
- CAS编号：79558-09-1
- 包装：5mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-20019
- 产品名称：L-165041 L-165041
- CAS编号：79558-09-1
- 包装：10mM * 1mLin DMSO
- 价格：550元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
