ChemicalBook CAS数据库列表 L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- CAS号:159190-45-1
- 英文名:L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- 中文名:L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- CBNumber:CB5353543
- 分子式:C8H18ClN3O2
- 分子量:223.7
- MOL File:159190-45-1.mol
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE化学性质
- 储存条件 :-20°C
- 溶解度 :DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
- 形态 :White to off-white solid.
安全信息
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :37/39-26-36
- WGK Germany :3
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE性质、用途与生产工艺
- 生物活性 L-NIL dihydrochloride 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂,其对 miNOS 的 IC50 值为3.3 μM。
-
靶点
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).
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体外研究
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
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体内研究
L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.
Animal Model: Adult male Balb/c (20-25 g). Dosage: 10 and 30 mg/kg. Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction. Result: Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE上下游产品信息
上游原料
下游产品
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE生产厂家
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
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- 公司名称:CAYMAN
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- 电子邮件:cayman@caymanchem.com
- 国家:美国
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- 公司名称:MedChemExpress
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- 公司名称:NOVABIO
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- 电子邮件:technical@calbiochem.com
- 国家:美国
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