1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID

生物活性体外研究体内研究 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID 试剂级价格

CAS号:1268335-33-6
英文名:1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid
中文名:1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
CBNumber:CB53361118
分子式:C10H11BO4
分子量:206
MOL File:1268335-33-6.mol

1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID化学性质

熔点 :150-151 °C
沸点 :402.7±55.0 °C(Predicted)
密度 :1.31±0.1 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO: 250 mg/mL (1213.59 mM)
酸度系数(pKa) :4.52±0.10(Predicted)
形态 :Solid
颜色 :White to off-white

1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID性质、用途与生产工艺

生物活性 AN3661，一种有效的抗疟疾先导化合物，靶向恶性疟原虫的切割和多腺苷酸特异性因子同源物亚基 3 (PfCPSF3)。AN3661 可抑制恶性疟原虫实验室适应的菌株(平均 IC50=32 nM)，Ugandan 野外分离株 (平均 IC50=64 nM) 和小鼠 P. berghei 和 P. falciparum 的感染。
体外研究

AN3661 is active at nanomolar (IC ₅₀ =20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is similarly active in ex vivo studies of fresh Ugandan field isolates (mean ex vivo IC ₅₀ =64 nM). AN3661 shows minimal cytotoxicity against mammalian cell lines, with the CC ₅₀ 60.5 μM against Jurkat cells, and all other CC ₅₀ values greater than the highest concentrations tested (25 μM or above).
AN3661 inhibits the stability of P. falciparum transcripts.

体内研究

AN3661 (50-200 mg.kg; p.o.; daily for 4 days) inhibits murine P. berghei infections with ED ₉₀ (4 days) 0.34 mg/kg.
AN3661 is administered orally for 4 days, beginning on the third day of infection, the ED ₉₀ 4 days after initiation of treatment is 0.57 mg/kg.

Animal Model:	P. berghei -infected mice (malaria model)
Dosage:	50, 100, 200 mg/kg
Administration:	Orally; daily for 4 days
Result:	Rapidly controlled parasitemias, with an ED ₉₀ of 0.34 mg/kg. Daily dosages of 50 mg/kg and 100 mg/kg extended survival, and mice treated with 200 mg/kg per day demonstrated long-term cures.