CS-2692
- CAS号:87134-87-0
- 英文名:R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
- 中文名:CS-2692
- CBNumber:CB5335703
- 分子式:C17H19Cl2NO
- 分子量:324.24
- MOL File:87134-87-0.mol
- 溶解度 :H2O: ≥5 mg/mL
- 形态 :solid
- 颜色 :white
- WGK Germany :3
CS-2692性质、用途与生产工艺
- 生物活性 SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是一种有效的选择性的多巴胺 D1 样受体拮抗剂，其对 D1 和 D5 受体的 Ki 分别为 0.2 nM 和 0.3 nM。SCH-23390 maleate 也是一种有效的人 5-HT2C 受体激动剂，Ki 为 9.3 nM。SCH-23390 maleate 与 5-HT2 和 5-HT1C 受体具有高亲和力。SCH-23390 maleate 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道，IC50 为 268 nM。
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靶点
D 1 Receptor
0.2 nM (Ki)
D 5 Receptor
0.3 nM (Ki)
5-HT 2C Receptor
9.3 nM (Ki)
GIRK
268 nM (IC 50 )
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体外研究
SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.
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体内研究
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D 1 receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O 2 conditions.
- 更新日期：2021/03/30
- 产品编号：S2834
- 产品名称：CS-2692 SCH-23390 maleate
- CAS编号：87134-87-0
- 包装：25mg
- 价格：7199.01元
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
