生物活性 体外研究 体内研究
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亚美克松

亚美克松,59643-91-3,结构式
亚美克松
  • CAS号:59643-91-3
  • 英文名:Imexon
  • 中文名:亚美克松
  • CBNumber:CB5274628
  • 分子式:C4H5N3O
  • 分子量:111.1
  • MOL File:59643-91-3.mol
亚美克松化学性质
  • 沸点 :231.6±23.0 °C(Predicted)
  • 密度 :2.26±0.1 g/cm3(Predicted)
  • 储存条件 :2-8°C
  • 溶解度 :Soluble in DMSO
  • 酸度系数(pKa) :4.79±0.20(Predicted)
  • 形态 :Solid
  • 颜色 :White to off-white
安全信息
  • WGK Germany :3

亚美克松性质、用途与生产工艺

  • 生物活性 Imexon (BM 06002) 是一种氮杂环丙烷类化合物,具有抗癌的功效。
  • 体外研究

    Imexon (BM 06002) induces oxidative stress in the ER, activates an ER stress response. Imexon (BM 06002) does not significantly alter the levels of eIF2B5, however there is a dose-dependent increase in the phosphorylation of eIF2alpha, as well as an increase in the levels of GTP exchange protein eIF2B2 in MiaPaCa-2, Panc-1, and BxPC3 cells. Imexon (BM 06002) induces single-stranded breaks in the human A375 melanoma cells but only significantly at the highest concentrations for each agent compared to controls. Imexon plus DTIC cytotoxicity is additive. Imexon (BM 06002) show inhibitory activities against MiaPaCa-2, Panc-1 and BxPC3, with IC 50 s of 275.5 ± 54.2, 147.4 ± 4.7 and 355.7 ± 114.7 μM.

  • 体内研究

    Imexon (BM 06002) in combination with DTIC results in an increase in the peak plasma imexon level in non-tumor-bearing mice. The combination of both drugs increases plasma imexon AUC by 22% (p=0.026). Imexon (BM 06002) (100 mg/kg/day, i.v.) treatment decreases the body weight of SCID mice bearing human A375 melanoma tumors, but there is no significant difference in tumor growth. Imexon (BM 06002) (100 mg/kg) in combination with GEM shows synergistic inhibition of Panc-1 tumor growth in SCID mice.

亚美克松上下游产品信息
上游原料
下游产品
亚美克松生产厂家
  • 公司名称:Wuhan NCE Biomedical Co.,Ltd.
  • 联系电话:4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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  • 公司名称:TargetMol中国(陶术生物)
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  • 电子邮件:marketing@tsbiochem.com
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  • 公司名称:南京世洲生物科技有限公司
  • 联系电话:025-85560043 15850508050
  • 电子邮件:cindy.huang@synzest.com
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  • 公司名称:SHANGHAI KEAN TECHNOLOGY CO., LTD.
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