二羟基喹酮

生物活性靶点体外研究体内研究二羟基喹酮试剂级价格

二羟基喹酮

CAS号:118876-58-7
英文名:NBQX DISODIUM SALT
中文名:二羟基喹酮
CBNumber:CB5274224
分子式:C12H8N4O6S
分子量:336.28
MOL File:118876-58-7.mol

二羟基喹酮化学性质

熔点 :361°C
密度 :1.6027 (rough estimate)
折射率 :1.6000 (estimate)
储存条件 :Inert atmosphere,2-8°C
溶解度 :methanol: 0.25 mg/mL
形态 :solid
酸度系数(pKa) :7.55±0.20(Predicted)
颜色 :yellow
水溶解性 :H2O: >10mg/mL
稳定性 :Freezer at -20°C
InChIKey :UQNAFPHGVPVTAL-UHFFFAOYSA-N

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36
WGK Germany :3

二羟基喹酮性质、用途与生产工艺

生物活性 NBQX (FG9202, NNC 079202) 是一种具有高选择性的 AMPA receptor (AMPAR) 的竞争性拮抗剂，具有抗癫痫的作用。
靶点
Target Value
AMPAR
()
体外研究

NBQX (FG9202) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.

体内研究

NBQX (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.
NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.

Animal Model:	Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)
Dosage:	20 mg/kg
Administration:	IP; for 3 days
Result:	Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.