YS-49 (Monohydrate)
- CAS号:132836-42-1
- 英文名:YS-49 (Monohydrate)
- 中文名:YS-49 (Monohydrate)
- CBNumber:CB52682027
- 分子式:C??H??BrNO?
- 分子量:0
- MOL File:132836-42-1.mol
- 形态 :Solid
- 颜色 :Off-white to gray
YS-49 (Monohydrate)性质、用途与生产工艺
- 生物活性 YS-49 (monohydrate) 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱，因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。
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靶点
PI3K/Akt
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体外研究
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.Cell Viability Assay
Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ(RAVSMC); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7) Incubation Time: 18 hours Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively. Western Blot Analysis
Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ Incubation Time: 18 hours Result: Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. -
体内研究
YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
Animal Model: Male Sprague Dawley rats (250-300 g) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 8 hours Result: Serum NOx levels were significantly reduced.
- 更新日期：2024/08/19
- 产品编号：HY-15477A
- 产品名称：YS-49 monohydrate
- CAS编号：
- 包装：5 mg
- 价格：767元
- 更新日期：2024/08/19
- 产品编号：HY-15477A
- 产品名称：YS-49 (Monohydrate) YS-49 monohydrate
- CAS编号：132836-42-1
- 包装：10mg
- 价格：1228元
- 公司名称：MedChemexpress LLC
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