J-147

生物活性靶点体外研究体内研究 J-147 试剂级价格

J-147

CAS号:1146963-51-0
英文名:J 147
中文名:J-147
CBNumber:CB52652639
分子式:C18H17F3N2O2
分子量:350.33
MOL File:1146963-51-0.mol

J-147化学性质

沸点 :412.8±55.0 °C(Predicted)
密度 :1.18±0.1 g/cm3(Predicted)
储存条件 :Sealed in dry,Room Temperature
溶解度 :DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM)
形态 :Powder
酸度系数(pKa) :0.80±0.50(Predicted)
颜色 :Off-white to pink
InChI :InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3
InChIKey :HYMZAYGFKNNHDN-UHFFFAOYSA-N
SMILES :C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F

J-147性质、用途与生产工艺

生物活性 J-147 是一种特别有效的，具有口服活性的神经保护剂，可增强认知能力。J-147 可透过血脑屏障 (BBB)。J-147 抑制单胺氧化酶 B (MAO B) 和多巴胺转运体 (dopamine transporter)，EC50 分别为 1.88 μM 和 0.649 μM。J-147 有潜力用于阿尔茨海默氏症 (AD) 的研究。
靶点

MAO B; Dopamine transporter
体外研究

J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC ₅₀ value range of 0.06-0.115 μM) .

体内研究

J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t _1/2 ) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).

Animal Model:	24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls
Dosage:	200 ppm
Administration:	The diet was prepared by the addition of 200ppm; 6 months
Result:	While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147.