ChemicalBook CAS数据库列表 4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE
- CAS号:212332-35-9
- 英文名:4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE
- 中文名:4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE
- CBNumber:CB52453441
- 分子式:C20H26N2O9
- 分子量:0
- MOL File:212332-35-9.mol
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE化学性质
- 熔点 :123-125°C
- 储存条件 :Desiccate at RT
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 颜色 :White to Off-White
- 水溶解性 :Soluble to 100 mM in water
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE性质、用途与生产工艺
- 生物活性 TC-2559 difumarate 是 CNS 选择性，具有口服活性的烟碱乙酰胆碱受体 (nAChR) α4β2 亚型的部分激动剂。TC-2559 difumarate 对 α2β4、α4β4 和 α3β4 受体表现出选择性，EC50在 10-30 µM 范围内。
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体内研究
TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice.
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats.Animal Model: Adult male mice (body weight 15-30 g) (formalin test) Dosage: 1, 3, 10 mg/kg Administration: I.p. Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI)) Dosage: 0.3, 1, 3 mg/kg Administration: I.p. Result: Significantly reversed CCI induced the paw withdrawal threshold decreases.
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE上下游产品信息
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下游产品
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE 试剂级价格
- 更新日期：2024/04/30
- 产品编号：HY-107667
- 产品名称：TC-2559 fumarate
- CAS编号：
- 包装：1 mg
- 价格：670元
- 更新日期：2024/04/30
- 产品编号：HY-136207
- 产品名称：TC-2559 difumarate
- CAS编号：
- 包装：50 mg
- 价格：23306元
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5729
- 优势度：77
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