BMY-25271

生物活性靶点体内研究

CAS号:78441-82-4
英文名:N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
中文名:BMY-25271
CBNumber:CB52216356
分子式:C12H19N5O2S2
分子量:329.44
MOL File:78441-82-4.mol

BMY-25271化学性质

BMY-25271性质、用途与生产工艺

生物活性 BMY-25271 是一个组胺 H2 受体 (histamine H2 receptor) 拮抗剂。
靶点

Histamine H2 receptor
体内研究

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED ₅₀ values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid.

BMY-25271上下游产品信息

上游原料

下游产品

BMY-25271生产厂家