ChemicalBook CAS数据库列表 硫链丝菌素
硫链丝菌素
- CAS号:1393-48-2
- 英文名:THIOSTREPTON
- 中文名:硫链丝菌素
- CBNumber:CB5204768
- 分子式:C72H85N19O18S5
- 分子量:1664.89
- MOL File:1393-48-2.mol
硫链丝菌素化学性质
- 熔点 :248-257°C (dec.)
- 比旋光度 :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
- 密度 :1.0824 (rough estimate)
- 折射率 :1.6700 (estimate)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :Soluble in DMSO or chloroform
- 形态 :Off-white powder
- 酸度系数(pKa) :10.43±0.46(Predicted)
- 颜色 :Off-white
- 水溶解性 :0.24g/L(28 ºC)
- Merck :13,9440
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
安全信息
硫链丝菌素性质、用途与生产工艺
- 生物活性 Thiostrepton 是一种抗生素，可选择性抑制 FOXM1。FOXM1 与 YAP/TEAD 复合物结合。YAP/TEAD/FOXM1 复合物在控制细胞周期的基因调控区域结合可能会影响细胞增殖。
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体外研究
Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A.
Cell Viability Assay
Cell Line: A2780 and HEC-1A cells Concentration: 0.01, 0.1, 1, 10, 100, 1000 μM Incubation Time: 48 hours Result: The IC 50 s are 1.10 μM in A2780 and 2.22 μM in HEC-1A, respectively. -
体内研究
Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls.
Animal Model: Athymic (BALB/c nu/nu) nude mice bearing A4573 cells Dosage: 17 mg/kg Administration: Administered i.p. Result: Treatment inhibited the growth of EWS-derived tumors in vivo.
硫链丝菌素上下游产品信息
上游原料
下游产品
硫链丝菌素 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW13934821
- 产品名称：硫链丝菌肽
- CAS编号：1393-48-2
- 包装：1G
- 价格：2042元
- 更新日期：2024/11/08
- 产品编号：S4354
- 产品名称：硫链丝菌素 Thiostrepton
- CAS编号：1393-48-2
- 包装：50mg
- 价格：803.52元
硫链丝菌素生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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