Bimosiamose
- CAS号:187269-40-5
- 英文名:Bimosiamose
- 中文名:Bimosiamose
- CBNumber:CB51401694
- 分子式:C46H54O16
- 分子量:862.92
- MOL File:187269-40-5.mol
- 熔点 :115-117°
- 沸点 :1051.0±65.0 °C(Predicted)
- 密度 :1.417±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM) - 形态 :A crystalline solid
- 酸度系数(pKa) :3.95±0.10(Predicted)
- 颜色 :White to off-white
Bimosiamose性质、用途与生产工艺
- 生物活性 Bimosiamose (TBC-1269) 是一种非寡糖泛-selectin 拮抗剂,对 E-selectin,P-selectin 和 L-selectin 的 IC50 分别为 88 μM,20 μM 和 86μM。Bimosiamose 具有抗炎作用。
-
靶点
IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)
-
体外研究
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
-
体内研究
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.
Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R) Dosage: 25 mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls.
- 更新日期:2024/04/30
- 产品编号:HY-106139
- 产品名称:Bimosiamose Bimosiamose
- CAS编号:187269-40-5
- 包装:1mg
- 价格:600元
- 更新日期:2024/04/30
- 产品编号:HY-106139
- 产品名称:Bimosiamose Bimosiamose
- CAS编号:187269-40-5
- 包装:5mg
- 价格:1800元
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:CAYMAN
- 联系电话:--
- 电子邮件:cayman@caymanchem.com
- 国家:美国
- 产品数:6618
- 优势度:81
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58