化合物SB 204990
- CAS号:154566-12-8
- 英文名:SB 204990
- 中文名:化合物SB 204990
- CBNumber:CB51363884
- 分子式:C18H22Cl2O5
- 分子量:389.27
- MOL File:154566-12-8.mol
- 熔点 :87-89 °C
- 沸点 :571.6±40.0 °C(Predicted)
- 密度 :1.332±0.06 g/cm3(Predicted)
- 溶解度 :DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :4.33±0.10(Predicted)
- 颜色 :White to off-white
- InChI :InChI=1/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/s3
- InChIKey :YTRNLFYTHYWDAU-RVFWCEGZNA-N
- SMILES :O1[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C[C@@](O)(CC(O)=O)C1=O |&1:1,17,r|
化合物SB 204990性质、用途与生产工艺
- 生物活性 SB 204990是ATP柠檬酸裂解酶 (ACLY) 的有效特异性抑制剂。
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靶点
ACLY.
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体外研究
SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
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体内研究
SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
- 更新日期：2024/11/08
- 产品编号：HY-16450
- 产品名称：化合物SB 204990 SB 204990
- CAS编号：154566-12-8
- 包装：5mg
- 价格：1200元
- 更新日期：2024/11/08
- 产品编号：HY-16450
- 产品名称：化合物SB 204990 SB 204990
- CAS编号：154566-12-8
- 包装：10mM * 1mLin DMSO
- 价格：1320元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
