RENTIAPRIL RACEMATE
- CAS号:72679-47-1
- 英文名:rentiapril
- 中文名:RENTIAPRIL RACEMATE
- CBNumber:CB51321949
- 分子式:C13H15NO4S2
- 分子量:313.39
- MOL File:72679-47-1.mol
- 沸点 :553.7±50.0 °C(Predicted)
- 密度 :1.451±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 酸度系数(pKa) :3.02±0.40(Predicted)
- 颜色 :White to off-white
RENTIAPRIL RACEMATE性质、用途与生产工艺
- 生物活性 Rentiapril racemate (SA-446 racemate) 是 Rentiapril 的外消旋体。Rentiapril 是一种血管紧张素转换酶 (ACE) 抑制剂。
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靶点
Angiotensin converting enzyme (ACE)
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体内研究
A three-months toxicity study of an angiotensin converting enzyme (ACE) inhibitor, Rentiapril (CAS 80830-42-8), is performed in Sprague-Dawley rats by oral administration. The dose levels of 0, 30, 125, 500 and 1000 mg/kg are tested in both sexes, in which each experimental group comprised 10 rats. Another ACE inhibitor, captopril, is used as a reference compound. Rentiapril at the highest dose of 1000 mg/kg causes low food consumption and death of some animals with signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume and serum BUN level, and decreases in levels of various erythrocytic parameters. Kidney weight is increased dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia and interstitial cell infiltration. Similar, but mild, changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decrease bone marrow erythropoiesis and hepatocytic vacuolar degeneration. There is no pathological alteration in rats from other Rentiapril-treated groups, as well as in controls. These results indicate that the no-effect dose of Rentiapril in rats by three months oral administration is 30 mg/kg in female and 125 mg/kg in male.
- 更新日期:2024/04/30
- 产品编号:HY-U00074
- 产品名称:RENTIAPRIL RACEMATE Rentiapril racemate
- CAS编号:72679-47-1
- 包装:1 mg
- 价格:909元
- 更新日期:2024/04/30
- 产品编号:HY-U00074
- 产品名称:RENTIAPRIL RACEMATE Rentiapril racemate
- CAS编号:72679-47-1
- 包装:5 mg
- 价格:2000元
- 公司名称:LGM Pharma
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