ChemicalBook CAS数据库列表 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- CAS号:1482-50-4
- 英文名:11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- 中文名:11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- CBNumber:CB4757474
- 分子式:C21H32O5
- 分子量:364.48
- MOL File:1482-50-4.mol
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE化学性质
- 熔点 :>173°C (dec.)
- 沸点 :544.5±50.0 °C(Predicted)
- 密度 :1.249±0.06 g/cm3(Predicted)
- 储存条件 :Refrigerator
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :12.50±0.70(Predicted)
- 颜色 :White to Off-White
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE性质、用途与生产工艺
- 生物活性 5β-Dihydrocortisol，氢化可的松 (Cortisol) 的代谢产物，是潜在的盐皮质激素。5β-Dihydrocortisol 可以增强糖皮质激素的活性以提高眼压。5β-Dihydrocortisol 可引起乳腺癌细胞凋亡。
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体外研究
5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC 50 of 27.59 μM.
5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells.
5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak.Cell Viability Assay
Cell Line: MCF-7 and HEK 293 cells Concentration: 10, 20, 40, 60, 80, 100 μM Incubation Time: 48 hours Result: Inhibited the viability of MCF-7 cells in a dose-dependent manner.
No toxicity in terms of cell viability was observed with HEK293 cell line.Apoptosis Analysis
Cell Line: MCF-7 cells Concentration: 14 μM Incubation Time: 24 hours Result: Induced 35.6% and 2.5% of early and late apoptosis. -
体内研究
5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits.
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE上下游产品信息
上游原料
下游产品
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-N3995
- 产品名称：11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol
- CAS编号：1482-50-4
- 包装：5mg
- 价格：2800元
- 更新日期：2024/11/08
- 产品编号：HY-N3995
- 产品名称：11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol
- CAS编号：1482-50-4
- 包装：10mM * 1mLin DMSO
- 价格：3080元
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE生产厂家
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
