2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶

2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶化学性质

熔点 :300
沸点 :355.66°C (rough estimate)
密度 :1.2067 (rough estimate)
折射率 :1.5890 (estimate)
储存条件 :Refrigerator
溶解度 :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
形态 :A crystalline solid
酸度系数(pKa) :7.72±0.30(Predicted)
颜色 :White to light yellow
CAS 数据库 :105650-23-5(CAS DataBase Reference)
(IARC)致癌物分类 :2B (Vol. 56) 1993

安全信息

2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶性质、用途与生产工艺

生物活性 PhIP 是在熟肉中形成的杂环芳香胺 (HAA)，是一种可能的致癌物。具有 DNA 破坏性和诱变性。 PhIP 还具有雌激素活性，可能有助于其组织特异性致癌性。
体外研究

PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer.
体内研究

In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents.
类别有毒物品
可燃性危险特性可燃;燃烧产生有毒氮氧化物烟雾
储运特性库房通风低温干燥
灭火剂干粉、泡沫、砂土、二氧化碳, 雾状水

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