顺式-8，11，14-二十烷三烯酸甲酯
- CAS号:1783-84-2
- 英文名:CIS-8,11,14-EICOSATRIENOIC ACID
- 中文名:顺式-8，11，14-二十烷三烯酸甲酯
- CBNumber:CB4667988
- 分子式:C20H34O2
- 分子量:306.48
- MOL File:1783-84-2.mol
- 沸点 :200°C(lit.)
- 密度 :0.917±0.06 g/cm3(Predicted)
- 折射率 :n
20/D 1.478(lit.) - 闪点 :144 °F
- 储存条件 :-20°C
- 溶解度 :chloroform: 50 mg/mL, clear, colorless
- 酸度系数(pKa) :4.77±0.10(Predicted)
- 形态 :Liquid
- 颜色 :Colourless to Light Yellow
- BRN :1796533
- 稳定性 :Light Sensitive
顺式-8，11，14-二十烷三烯酸甲酯性质、用途与生产工艺
- 生物活性 Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) 是 20 个碳的 ω-6 脂肪酸，具有抗炎和抗增殖活性。Dihomo-γ-linolenic acid 能减弱载脂蛋白 E 缺陷小鼠模型模型的动脉粥样硬化。
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靶点
Human Endogenous Metabolite
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体外研究
Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
Cell Line: THP-1 macrophages Concentration: 50 μM (pre-treated) Incubation Time: 24 hours Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727. -
体内研究
Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Animal Model: Female nude mice (48 four-week old) Dosage: 8 mg/mouse Administration: Oral gavage, twice a week, for 35 days Result: Suppressed metastasis potential in D5D-KD tumors.
- 更新日期：2024/11/11
- 产品编号：XW17838421
- 产品名称：顺式-8,11,14-二十碳三烯酸
- CAS编号：1783-84-2
- 包装：5MG
- 价格：219元
- 更新日期：2024/11/08
- 产品编号：E0640
- 产品名称：全顺-8,11,14-二十碳三烯酸 all cis-8,11,14-Eicosatrienoic Acid
- CAS编号：1783-84-2
- 包装：50mg
- 价格：985元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
