CKI-7
- CAS号:120615-25-0
- 英文名:CKI-7
- 中文名:CKI-7
- CBNumber:CB4503226
- 分子式:C11H12ClN3O2S
- 分子量:285.75
- MOL File:120615-25-0.mol
- 熔点 :188-190°C
- 沸点 :499.7±55.0 °C(Predicted)
- 密度 :1.432±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :H2O: 9 mg/mL
- 形态 :solid
- 酸度系数(pKa) :7.80±0.50(Predicted)
- 颜色 :white
CKI-7性质、用途与生产工艺
- 生物活性 CKI-7 free base 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC50 为 6 μM，Ki 为 8.5 μM。CKI-7 free base 选择性抑制 Cdc7 激酶，还抑制 SGK，S6K1 以及 MSK1。CKI-7 free base 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。
-
靶点
CK1
6 μM (IC 50 )
CK1
8.5 μM (Ki)
Cdc7
SGK
S6K1
MSK1
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体外研究
CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.RT-PCR
Cell Line: Mouse ES cells Concentration: 0.1-10 μM Incubation Time: 5 days Result: Significantly increased the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner. Western Blot Analysis
Cell Line: Mouse ES cells Concentration: 5 μM Incubation Time: 5 days Result: Suppressed SFEB-induced β-catenin stabilization on day 5. -
体内研究
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.
- 更新日期：2024/11/08
- 产品编号：HY-133028
- 产品名称：CKI-7 CKI-7 free base
- CAS编号：120615-25-0
- 包装：5mg
- 价格：850元
- 更新日期：2024/11/08
- 产品编号：HY-133028
- 产品名称：CKI-7 CKI-7 free base
- CAS编号：120615-25-0
- 包装：10mg
- 价格：1500元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
