BOHEMINE
- CAS号:189232-42-6
- 英文名:BOHEMINE
- 中文名:BOHEMINE
- CBNumber:CB4503170
- 分子式:C18H24N6O
- 分子量:340.42
- MOL File:189232-42-6.mol
- 熔点 :101-103 °C
- 沸点 :589.4±60.0 °C(Predicted)
- 密度 :1.27±0.1 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,2-8°C
- 溶解度 :chloroform: 50 mg/mL, soluble
- 形态 :powder
- 酸度系数(pKa) :14.94±0.10(Predicted)
- 颜色 :White to off-white
- WGK Germany :3
BOHEMINE性质、用途与生产工艺
- 生物活性 Bohemine是CDK抑制剂，对Cdk2/cyclin E, Cdk2/cyclin A和Cdk9/cyclin T1的IC50值分别为4.6, 83和2.7 μM。
-
靶点
Target Value Cdk9/cyclin T1
()2.7 μM Cdk2/cyclin E
()4.6 μM Cdk2/cyclin A
()83 μM -
体外研究
Bohemine (0-30 µM; 72 hours; ME-750 cells) treatment inhibits cell growth. Addition of Bohemine at concentrations in the range of 1-10 µM results in a short-term arrest of growth and of monoclonal antibody production. The short-term suppression of cell functions is followed by a significant temporary increase of specific growth rate and of specific production rate.
Hybridoma cells are retarded both at the G1/S boundary and at the G2/M boundary, depending on Bohemine (0-30 µM) concentration.
T-lymphoblastic cell line CEM is treated by Bohemine, five proteins are found to be downregulated, namely α-enolase, triosephosphate isomerase, initiation factor 5A, and α- and β-subunits of Rho GDP-dissociation inhibitor 1. These proteins play significant roles in glycolysis, proteosynthesis, and in cytoskeleton rearrangement.
Bohemine inhibits growth of human tumor cell lines with an IC 50 of 27 µM.Cell Viability Assay
Cell Line: Mouse hybridoma ME-750 cells Concentration: 0 µM, 1 µM, 3 µM, 10 µM and 30 µM Incubation Time: 72 hours Result: At 10 µM and 30 µM concentrations, the viable cell count was significantly lower with respect to control, i.e., 77% and 48%, respectively. -
体内研究
Bohemine (50 mg/kg; intravenous injection; BALB/c mice) treatment shows C max is 72,308 nM, observed clearance is 0.23 L/h and T 1/2 is 1.39 h.
Animal Model: BALB/c mice bearing the colon 26 murine tumor Dosage: 50 mg/kg Administration: Intravenous injection (Pharmacokinetic Analysis) Result: C max is 72,308 nM, observed clearance is 0.23 L/h and T 1/2 is 1.39 h.
- 更新日期：2024/11/08
- 产品编号：S6531
- 产品名称：BOHEMINE Bohemine
- CAS编号：189232-42-6
- 包装：5mg
- 价格：794.57元
- 更新日期：2024/11/08
- 产品编号：S6531
- 产品名称：BOHEMINE Bohemine
- CAS编号：189232-42-6
- 包装：25mg
- 价格：2432.89元
- 公司名称：Target molecule Corp.
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