罗红霉素杂质 A
- CAS号:59319-72-1
- 英文名:ERYTHROMYCIN A DIHYDRATE
- 中文名:罗红霉素杂质 A
- CBNumber:CB4502522
- 分子式:C37H67NO13.H2O
- 分子量:751.945
- MOL File:59319-72-1.mol
- 熔点 :197.6 °C
- WGK Germany :2
- RTECS号 :KF4375000
罗红霉素杂质 A性质、用途与生产工艺
- 生物活性 Erythromycin dihyrate 是由放线菌产生的大环内酯类抗生素 (antibiotic)，具有广泛的抗菌活性。Erythromycin dihyrate 通过结合细菌的 50S 核糖体亚基而起作用，并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成，而不会影响核酸的合成。
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体外研究
Erythromycin dihyrate inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively.
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体内研究
Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls.
Animal Model: Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 cells Dosage: 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg Administration: Gastric intubation; 30-120 days Result: Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice.
- 公司名称：SIGMA
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- 国家：瑞士
- 产品数：6896
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