Porcupine-IN-1

Porcupine-IN-1化学性质

储存条件 :Store at -20°C
溶解度 :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: slightly soluble
形态 :A crystalline solid
颜色 :White to off-white

Porcupine-IN-1性质、用途与生产工艺

生物活性 Porcn-IN-1 是有效的 porcupine 抑制剂，IC50 值为 0.5±0.2 nM。
靶点

IC50: 0.5±0.2 nM (Porcupine inhibitor)
体外研究

Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.
体内研究

Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).

Porcupine-IN-1上下游产品信息

上游原料

下游产品

Porcupine-IN-1 试剂级价格

Porcupine-IN-1生产厂家