DYNORPHIN A (1-10)
- CAS号:79994-24-4
- 英文名:H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
- 中文名:DYNORPHIN A (1-10)
- CBNumber:CB4395153
- 分子式:C57H91N19O12
- 分子量:1234.45
- MOL File:79994-24-4.mol
- 储存条件 :-15°C
- 溶解度 :Soluble in DMSO
DYNORPHIN A (1-10)性质、用途与生产工艺
- 生物活性 Dynorphin A (1-10) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。
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靶点
κ-opioid receptor
NMDA receptor -
体外研究
Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC 50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors.
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