ChemicalBook CAS数据库列表 PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
- CAS号:112208-00-1
- 英文名:PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
- 中文名:PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
- CBNumber:CB4345219
- 分子式:C81H156N10O13S
- 分子量:1510.23
- MOL File:112208-00-1.mol
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH化学性质
- 沸点 :1408.0±65.0 °C(Predicted)
- 密度 :1.054±0.06 g/cm3(Predicted)
- 储存条件 :-15°C
- 溶解度 :Soluble to 1 mg/ml in 50% Ethanol / H2O
- 形态 :Lyophilized solid
- 酸度系数(pKa) :3.27±0.10(Predicted)
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH性质、用途与生产工艺
- 用途 本品主要用于实验室有机合成中和化工医药研发过程中。
- 生物活性 Pam3CSK4 是一种 Toll 样受体 1/2 (TLR1/2) 激动剂，对人 TLR1/2 的 EC50 为 0.47 ng/mL。
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体外研究
Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus . -
体内研究
Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.
Animal Model: Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2 tm1Kir /J (TLR2 -deficient) mice Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.); once a day for 9 days Result: After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH上下游产品信息
上游原料
下游产品
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH 试剂级价格
- 更新日期：2022/04/29
- 产品编号：HY-P1180
- 产品名称：PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Pam3CSK4
- CAS编号：112208-00-1
- 包装：1mg
- 价格：6800元
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH生产厂家
- 公司名称：AXXORA, LLC
- 联系电话：--
- 电子邮件：alexis-ch@alexis-corp.com
- 国家：瑞士
- 产品数：1104
- 优势度：80
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