CA-4948

生物活性靶点 CA-4948 试剂级价格

CA-4948化学性质

熔点 :>294°C (dec.)
密度 :1.444±0.06 g/cm3(Predicted)
储存条件 :-20°C Freezer, Under inert atmosphere
溶解度 :DMSO (Slightly), Methanol (Slightly)
酸度系数(pKa) :10.41±0.43(Predicted)
形态 :Solid
颜色 :Pale Yellow to Brown
InChI :InChI=1S/C21H19N7O3/c22-18-5-4-13(11-23-18)15-2-1-3-16(26-15)20(29)25-14-10-17-19(24-12-14)27-21(31-17)28-6-8-30-9-7-28/h1-5,10-12H,6-9H2,(H2,22,23)(H,25,29)
InChIKey :RWIMETUXCNDSLE-UHFFFAOYSA-N
SMILES :C1(C2=CC=C(N)N=C2)=NC(C(NC2=CN=C3N=C(N4CCOCC4)OC3=C2)=O)=CC=C1

CA-4948性质、用途与生产工艺

生物活性 IRAK4-IN-2 是一种可逆性激酶抑制剂，在TLR和IL-1R信号级联反应中，调节IRAK4的功能。
靶点
Target Value
IRAK4
()
用途一种可逆性激酶抑制剂，在TLR和IL-1R信号级联反应中，调节IRAK4的功能。在体内外实验中，具有良好的药代动力学特征和抗肿瘤活性。
CA-4948 is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. CA-4948 exhibited the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL PDX models. Furthermore, CA-4948 was efficacious in ABC-DLBCL PDX tumors containing activating mutations in both TLR/IL-1R and BCR signaling pathways (MYD88 and CD79B double mutants).

CA-4948上下游产品信息

上游原料

下游产品

CA-4948 试剂级价格

CA-4948生产厂家

Target	Value
IRAK4 ()