878143-03-4
- CAS号:878143-03-4
- 英文名:Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
- 中文名:878143-03-4
- CBNumber:CB43339693
- 分子式:C21H39NaO6P2
- 分子量:472.47
- MOL File:878143-03-4.mol
- 储存条件 :Store at -20°C, protect from light, stored under nitrogen
- 溶解度 :DMSO : 2 mg/mL (3.73 mM; Need ultrasonic)|
- 形态 :Solid
- 颜色 :White to off-white
- 水溶解性 :Water : 2 mg/mL (3.73 mM; Need ultrasonic)
878143-03-4性质、用途与生产工艺
- 生物活性 Digeranyl bisphosphonate (DGBP) 是一种有效的香叶基焦磷酸香叶酯 (GGPP) 合酶抑制剂,其抑制 Rac1 的香叶酰香叶酰化。
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靶点
Rac1
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体外研究
Digeranyl bisphosphonate (DGBP) impairs geranylgeranylation. To examine if Digeranyl bisphosphonate modulates Rac1 activity, cells are exposed to vehicle or Digeranyl bisphosphonate. Rac1 activation increases significantly after chrysotile exposure, whereas the activity in Digeranyl bisphosphonate -treated cells is reduced to control levels. Digeranyl bisphosphonate also decreases H 2 O 2 generation in chrysotile-exposed macrophages.
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体内研究
To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day. Mice exposed to saline have normal lung architecture with vehicle and Digeranyl bisphosphonate treatment. Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal. To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day. Digeranyl bisphophonate (0.2 mg/kg/day)-treated mice show significantly less hydroxyproline compared to vehicle-treated mice exposed to Bleomycin.
- 更新日期:2024/08/19
- 产品编号:HY-U00145
- 产品名称:878143-03-4 Digeranyl bisphosphonate
- CAS编号:878143-03-4
- 包装:1mg
- 价格:3200元
- 更新日期:2024/08/19
- 产品编号:HY-U00145
- 产品名称:878143-03-4 Digeranyl bisphosphonate
- CAS编号:878143-03-4
- 包装:5mg
- 价格:6400元
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