327610-87-7
- CAS号:327610-87-7
- 英文名:NO-prednisolone
- 中文名:327610-87-7
- CBNumber:CB43175563
- 分子式:C29H33NO9
- 分子量:539.57
- MOL File:327610-87-7.mol
- 沸点 :736.2±60.0 °C(Predicted)
- 密度 :1.39±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 酸度系数(pKa) :12.30±0.70(Predicted)
- 颜色 :White to yellow
327610-87-7性质、用途与生产工艺
- 生物活性 NO-prednisolone 是释放一氧化氮 (NO) 的 Prednisolone 衍生物。NO-prednisolone 有效刺激体内 IL-10 产生。
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靶点
IL-10
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体外研究
NO-prednisolone (NCX-1015), an NO-releasing derivative of Prednisolone, is demonstrated to be more effective than Prednisolone in reducing inflammation, inhibiting cytokine and chemokine generation, and up-regulating the expression of the steroid-sensitive cell-surface marker CD163 in human peripheral blood mononuclear cells Incubation of PBMCs with NO-prednisolone (NCX-1015) and Prednisolone produces a concentration-dependent activation of CD163. NO-prednisolone is more potent than Prednisolone at inducing CD163 cell surface expression. The increased efficacy of NO-prednisolone, compared with the parent molecule Prednisolone, is also observed when assessing inhibition of LPS induced IL-1β production.
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体内研究
In vivo treatment with NO-prednisolone (NCX-1015) potently stimulates IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation. The two doses of NO-prednisolone tested, 0.5 and 5 mg/kg/day (equivalent to 0.33 and 3.3 mg/kg/day prednisone, respectively) effectively attenuates the severity of the wasting syndrome, ameliorates the colitis score, and reduces the colonic myeloperoxidase (MPO) activity. NO-prednisolone administration also reduces the colonic mRNA and protein content of tumor necrosis factor-α, IL-12, and IFN-γ. NO-prednisolone also reduces the expression of inducible NO synthase and cyclooxygenase-2 but in contrast does not inhibit colonic expression of IL-10 mRNA or protein. In fact, IL-10 expression is enhanced in mice treated with NO-prednisolone.
- 更新日期:2024/04/30
- 产品编号:HY-101757
- 产品名称:327610-87-7 NO-prednisolone
- CAS编号:327610-87-7
- 包装:1mg
- 价格:1590元
- 更新日期:2024/04/30
- 产品编号:HY-101757
- 产品名称:327610-87-7 NO-prednisolone
- CAS编号:327610-87-7
- 包装:5mg
- 价格:3500元
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