ChemicalBook CAS数据库列表 TLR2-IN-C29
TLR2-IN-C29
- CAS号:363600-92-4
- 英文名:TLR2-IN-C29
- 中文名:TLR2-IN-C29
- CBNumber:CB43168697
- 分子式:C16H15NO4
- 分子量:285.29
- MOL File:363600-92-4.mol
TLR2-IN-C29化学性质
- 熔点 :>192°C (dec.)
- 沸点 :505.7±50.0 °C(Predicted)
- 密度 :1.21±0.1 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :4.01±0.10(Predicted)
- 颜色 :Dark Orange
- 稳定性 :Moisture Sensitive
TLR2-IN-C29性质、用途与生产工艺
- 生物活性 TLR2-IN-C29 (C29)是一种 Toll-like receptor 2 (TLR2) 的抑制剂，可抑制TLR2/1和TLR2/6的信号传导。
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靶点
Target Value TLR2
() -
体外研究
C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.
C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.
C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.
Western Blot Analysis
Cell Line: THP-1 cells Concentration: 150 μM Incubation Time: 1 hours Result: Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C. Western Blot Analysis
Cell Line: Murine peritoneal macrophages Concentration: 50 μM Incubation Time: 1 hours Result: Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min.
Prevented P3C-induced degradation of IκBα at 15 and 30 min.
TLR2-IN-C29上下游产品信息
上游原料
下游产品
TLR2-IN-C29 试剂级价格
- 更新日期：2024/11/08
- 产品编号：S6597
- 产品名称：TLR2-IN-C29 TLR2-IN-C29
- CAS编号：363600-92-4
- 包装：5mg
- 价格：1170元
- 更新日期：2024/11/08
- 产品编号：S6597
- 产品名称：TLR2-IN-C29
- CAS编号：363600-92-4
- 包装：10mM (1mL in DMSO)
- 价格：1285.83元
TLR2-IN-C29生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
