生物活性 靶点 体外研究 TLR2-IN-C29 试剂级价格
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TLR2-IN-C29

生物活性 靶点 体外研究 TLR2-IN-C29 试剂级价格
TLR2-IN-C29,363600-92-4,结构式
TLR2-IN-C29
  • CAS号:363600-92-4
  • 英文名:TLR2-IN-C29
  • 中文名:TLR2-IN-C29
  • CBNumber:CB43168697
  • 分子式:C16H15NO4
  • 分子量:285.29
  • MOL File:363600-92-4.mol
TLR2-IN-C29化学性质
  • 熔点 :>192°C (dec.)
  • 沸点 :505.7±50.0 °C(Predicted)
  • 密度 :1.21±0.1 g/cm3(Predicted)
  • 储存条件 :Inert atmosphere,Store in freezer, under -20°C
  • 溶解度 :DMSO (Slightly), Methanol (Slightly)
  • 形态 :Solid
  • 酸度系数(pKa) :4.01±0.10(Predicted)
  • 颜色 :Dark Orange
  • 稳定性 :Moisture Sensitive

TLR2-IN-C29性质、用途与生产工艺

  • 生物活性 TLR2-IN-C29 (C29)是一种 Toll-like receptor 2 (TLR2) 的抑制剂，可抑制TLR2/1和TLR2/6的信号传导。
  • 靶点
    TargetValue
    TLR2
    ()
  • 体外研究

    C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.
    C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.
    C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.

    Western Blot Analysis

    Cell Line: THP-1 cells
    Concentration: 150 μM
    Incubation Time: 1 hours
    Result: Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C.

    Western Blot Analysis

    Cell Line: Murine peritoneal macrophages
    Concentration: 50 μM
    Incubation Time: 1 hours
    Result: Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min.
    Prevented P3C-induced degradation of IκBα at 15 and 30 min.
TLR2-IN-C29上下游产品信息
上游原料
下游产品
TLR2-IN-C29 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：S6597
  • 产品名称：TLR2-IN-C29 TLR2-IN-C29
  • CAS编号：363600-92-4
  • 包装：5mg
  • 价格：1170元
  • 更新日期：2024/11/08
  • 产品编号：S6597
  • 产品名称：TLR2-IN-C29
  • CAS编号：363600-92-4
  • 包装：10mM (1mL in DMSO)
  • 价格：1285.83元
TLR2-IN-C29生产厂家
  • 公司名称：北京索莱宝科技有限公司
  • 联系电话：010-50973130 4009686088
  • 电子邮件：3193328036@qq.com
  • 国家：中国
  • 产品数：29785
  • 优势度：68
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