萝卜硫苷

简介功效与作用生物活性体内研究萝卜硫苷试剂级价格

萝卜硫苷

CAS号:21414-41-5
英文名:GLUCORAPHANIN
中文名:萝卜硫苷
CBNumber:CB4313281
分子式:C12H23NO10S3
分子量:437.51
MOL File:21414-41-5.mol

萝卜硫苷化学性质

密度 :1.78±0.1 g/cm3 (20 ºC 760 Torr)
储存条件 :2-8°C
溶解度 :Methanol (Slightly), Water (Slightly)
形态 :White solid.
酸度系数(pKa) :-2.93±0.18(Predicted)
颜色 :White to light yellow
InChIKey :GMMLNKINDDUDCF-AAFOYFHQNA-N
SMILES :[C@@H]1(S/C(/CCCCS(C)=O)=N/OS(O)(=O)=O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |&1:0,17,20,22,24,r|

萝卜硫苷性质、用途与生产工艺

简介
萝卜硫苷是西兰花提取物的一个有效成分，也是萝卜硫素的前体药物，萝卜硫苷可以在体内转化为萝卜硫素，从而发挥抗癌抗氧化的功效。
功效与作用萝卜硫苷是一种主要存在于西兰花(Broccoli)种子和芽苗中的天然活性产物，经黑芥子酶或肠道微生物作用后可转化为萝卜硫素(Sulforaphane)。萝卜硫素是目前发现的Nrf2的最强激活剂之一，可通过激活Nrf2开启解毒、抗氧化、抗炎等多种细胞保护作用。
生物活性 Glucoraphanin 是存在于十字花科蔬菜中的硫代葡萄糖苷，是 Nrf2 诱导剂 sulforaphane 的前体，后者具有抗氧化、抗炎、抗癌的作用。
体内研究

Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2 ^−/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2 ^−/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice.
化学性质类白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于莱菔子。
用途抗癌抗氧化。
用途用于含量测定/鉴定/药理实验等。