OSU-T315
- CAS号:2070015-22-2
- 英文名:ILK-IN-2
- 中文名:OSU-T315
- CBNumber:CB43121106
- 分子式:C30H30F3N5O
- 分子量:533.59
- MOL File:2070015-22-2.mol
- 储存条件 :2-8°C(protect from light)
- 溶解度 :DMSO: ≥ 50 mg/mL (93.70 mM); Water: < 0.1 mg/mL (insoluble)
- 形态 :Solid
- 颜色 :White to off-white
OSU-T315性质、用途与生产工艺
- 生物活性 OSU-T315 (ILK-IN-2)是一种有效的 Integrin-Linked Kinase (ILK) 的抑制剂，其IC50值为0.6 μM。OSU-T315 可诱导自噬和细胞凋亡，这两者都是其抗增殖活性不可或缺的。OSU-T315 具有抗肿瘤活性。
-
靶点
Target Value ILK
(Cell-free assay)0.6 μM -
体外研究
OSU-T315 (Compound 22; 0-5 μM; 24 hours) exhibits high in vitro potency against a panel of prostate and breast cancer cell lines with a IC 50 range of 1-2.5 μM.
OSU-T315 (0-2.5 μM; 24 hours) can reduce YB-1, HER2, and EGFR expression; shows a modest suppressive effect on phosphorylated S6 levels, exhibits dose-dependent suppressive effects on the levels of phospho-ERK1/2 and phospho-p38, while that of phospho-JNK remains unaltered in PC-3 cell.
OSU-T315 (0-4 μM; 24 hours) causes autophagy through ILK inhibition.
Western Blot Analysis
Cell Line: PC-3 cells; MDA-MB-231 cells Concentration: 1 μM, 2 μM, 3 μM, 4 μM; 0.5 μM, 1 μM, 1.5 μM, 2 μM, 2.5 μM Incubation Time: 24 hours Result: Exhibited a dose-dependent decreasing effect on the phosphorylation of pS6, ERKs, and p38 in PC-3 cells and MDA-MB-231 cells. Cell Viability Assay
Cell Line: Prostate cancer cells: LNCaP, PC-3; breast cancer cells: MDA-MB-231, MDA-MB-468, SKBR3, MCF-7; PrEC and MEC cells Concentration: 0-5 μM Incubation Time: 24 hours Result: Suppressed cancer cells viability in breast and prostate cancer cells (IC (50), 1-2.5μM). Apoptosis Analysis
Cell Line: PC-3 cells Concentration: 1 μM, 2 μM, 3 μM, 4 μM Incubation Time: 24 hours Result: Induced accumulation of LC3-II and PARP cleavage. -
体内研究
OSU-T315 (Oral gavage; 25 mg/kg, 50 mg/kg; single daily; 35 days) has a suppressive effect of on PC-3 xenograft tumor growth .
No other obvious toxicity is observed in mice.Animal Model: Male NCr athymic nude mice with PC-3 tumor xenografts Dosage: 25 mg/kg; 50 mg/kg Administration: Oral gavage; single daily; 35 days Result: Resulted in suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively).
- 更新日期：2024/11/08
- 产品编号：HY-18676B
- 产品名称：OSU-T315 ILK-IN-2
- CAS编号：2070015-22-2
- 包装：2mg
- 价格：1200元
- 更新日期：2024/11/08
- 产品编号：HY-18676B
- 产品名称：OSU-T315 ILK-IN-2
- CAS编号：2070015-22-2
- 包装：5mg
- 价格：2400元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32165
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- 公司名称：InvivoChem
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- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
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- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
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- 公司名称：MedChemExpress
- 联系电话：--
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- 国家：美国
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