生物活性 靶点 体外研究 体内研究 OSU-T315 试剂级价格
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OSU-T315

生物活性 靶点 体外研究 体内研究 OSU-T315 试剂级价格
OSU-T315,2070015-22-2,结构式
OSU-T315
  • CAS号:2070015-22-2
  • 英文名:ILK-IN-2
  • 中文名:OSU-T315
  • CBNumber:CB43121106
  • 分子式:C30H30F3N5O
  • 分子量:533.59
  • MOL File:2070015-22-2.mol
OSU-T315化学性质
  • 储存条件 :2-8°C(protect from light)
  • 溶解度 :DMSO: ≥ 50 mg/mL (93.70 mM); Water: < 0.1 mg/mL (insoluble)
  • 形态 :Solid
  • 颜色 :White to off-white

OSU-T315性质、用途与生产工艺

  • 生物活性 OSU-T315 (ILK-IN-2)是一种有效的 Integrin-Linked Kinase (ILK) 的抑制剂，其IC50值为0.6 μM。OSU-T315 可诱导自噬和细胞凋亡，这两者都是其抗增殖活性不可或缺的。OSU-T315 具有抗肿瘤活性。
  • 靶点
    TargetValue
    ILK
    (Cell-free assay)     		0.6 μM
  • 体外研究

    OSU-T315 (Compound 22; 0-5 μM; 24 hours) exhibits high in vitro potency against a panel of prostate and breast cancer cell lines with a IC 50 range of 1-2.5 μM.
    OSU-T315 (0-2.5 μM; 24 hours) can reduce YB-1, HER2, and EGFR expression; shows a modest suppressive effect on phosphorylated S6 levels, exhibits dose-dependent suppressive effects on the levels of phospho-ERK1/2 and phospho-p38, while that of phospho-JNK remains unaltered in PC-3 cell.
    OSU-T315 (0-4 μM; 24 hours) causes autophagy through ILK inhibition.

    Western Blot Analysis

    Cell Line: PC-3 cells; MDA-MB-231 cells
    Concentration: 1 μM, 2 μM, 3 μM, 4 μM; 0.5 μM, 1 μM, 1.5 μM, 2 μM, 2.5 μM
    Incubation Time: 24 hours
    Result: Exhibited a dose-dependent decreasing effect on the phosphorylation of pS6, ERKs, and p38 in PC-3 cells and MDA-MB-231 cells.

    Cell Viability Assay

    Cell Line: Prostate cancer cells: LNCaP, PC-3; breast cancer cells: MDA-MB-231, MDA-MB-468, SKBR3, MCF-7; PrEC and MEC cells
    Concentration: 0-5 μM
    Incubation Time: 24 hours
    Result: Suppressed cancer cells viability in breast and prostate cancer cells (IC (50), 1-2.5μM).

    Apoptosis Analysis

    Cell Line: PC-3 cells
    Concentration: 1 μM, 2 μM, 3 μM, 4 μM
    Incubation Time: 24 hours
    Result: Induced accumulation of LC3-II and PARP cleavage.
  • 体内研究

    OSU-T315 (Oral gavage; 25 mg/kg, 50 mg/kg; single daily; 35 days) has a suppressive effect of on PC-3 xenograft tumor growth .
    No other obvious toxicity is observed in mice.

    Animal Model: Male NCr athymic nude mice with PC-3 tumor xenografts
    Dosage: 25 mg/kg; 50 mg/kg
    Administration: Oral gavage; single daily; 35 days
    Result: Resulted in suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively).
OSU-T315上下游产品信息
上游原料
下游产品
OSU-T315 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-18676B
  • 产品名称：OSU-T315 ILK-IN-2
  • CAS编号：2070015-22-2
  • 包装：2mg
  • 价格：1200元
  • 更新日期：2024/11/08
  • 产品编号：HY-18676B
  • 产品名称：OSU-T315 ILK-IN-2
  • CAS编号：2070015-22-2
  • 包装：5mg
  • 价格：2400元
OSU-T315生产厂家
  • 公司名称：上海超岚化工科技中心
  • 联系电话：021-QQ：65489617 15618227136
  • 电子邮件：Sales@ATKchemical.com
  • 国家：中国
  • 产品数：7266
  • 优势度：58
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