孕二烯二酮

孕二烯二酮化学性质

熔点 :188-190°
比旋光度 :D26 -61° (c = 1 in chloroform)
沸点 :463.3±45.0 °C(Predicted)
密度 :1.10±0.1 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :DMSO: 5 mg/mL
形态 :powder
颜色 :light yellow
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChIKey :WDXRGPWQVHZTQJ-OSJVMJFVSA-N
SMILES :C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C/C)/C(=O)C3)CC2
LogP :3.650 (est)

安全信息

孕二烯二酮性质、用途与生产工艺

生物活性 Z-guggulsterone 是印度阿育吠陀药用植物 Commiphora mukul 的成分，通过引起细胞凋亡 (apoptosis) 来抑制人前列腺癌细胞的生长。 Z-guggulsterone 通过抑制 VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。
靶点

VEGF-R2

Akt

体外研究

Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC.

Western Blot Analysis

Cell Line:	Vascular endothelial growth factor (VEGF)
Concentration:	10, 20 μM
Incubation Time:	24 or 48 hours
Result:	Caused a decrease in the level of VEGF-R2 protein in HUVEC.

体内研究

Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight.

Animal Model:	Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs
Dosage:	1 mg
Administration:	Oral; 5 times/week
Result:	Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.

孕二烯二酮上下游产品信息

上游原料

下游产品

孕二烯二酮试剂级价格

孕二烯二酮生产厂家

39025-23-5, 孕二烯二酮相关搜索: