CYM 9484

CAS号:1383478-94-1
英文名:N-[4-[(DiMethylaMino)sulfonyl]phenyl]-4-(hydroxydiphenylMethyl)-1-piperidinecarbothioaMide
中文名:CYM 9484
CBNumber:CB42696076
分子式:C27H31N3O3S2
分子量:509.68
MOL File:1383478-94-1.mol

CYM 9484化学性质

CYM 9484性质、用途与生产工艺

生物活性 CYM 9484 是一种选择性强效神经肽 Y (NPY) Y2 受体拮抗剂，IC50 值为 19 nM。
靶点

NPYY ₂ receptor

19 nM (IC ₅₀ )
体外研究

SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC ₅₀ value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates.

CYM 9484上下游产品信息

上游原料

下游产品

CYM 9484 试剂级价格

CYM 9484生产厂家