生物活性 靶点 体外研究 体内研究 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 试剂级价格
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ChemicalBook  CAS数据库列表  3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

生物活性 靶点 体外研究 体内研究 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 试剂级价格
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione,941575-71-9,结构式
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
  • CAS号:941575-71-9
  • 英文名:3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
  • 中文名:3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
  • CBNumber:CB42695130
  • 分子式:C21H13BrN2O3
  • 分子量:421.24
  • MOL File:941575-71-9.mol
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione化学性质
  • 沸点 :643.5±55.0 °C(Predicted)
  • 密度 :1?+-.0.1 g/cm3(Predicted)
  • 储存条件 :room temp
  • 溶解度 :DMSO: ≥15mg/mL
  • 形态 :powder
  • 酸度系数(pKa) :7.44±0.60(Predicted)
  • 颜色 :light orange to dark orange
安全信息
  • 危险品标志 :T
  • 危险类别码 :25
  • 安全说明 :45
  • 危险品运输编号 :UN 2811 6.1 / PGIII
  • WGK Germany :3

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione性质、用途与生产工艺

  • 生物活性 BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
  • 靶点

    GSK-3α

    16 nM (IC 50 )

    GSK-3β

    21 nM (IC 50 )

  • 体外研究

    BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
    BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.

    Western Blot Analysis

    Cell Line: Human SMA fibroblasts
    Concentration: 20 μM, 25 μM, 30 μM
    Incubation Time: 72 hours
    Result: Led to a 7-fold increase in SMN levels at 25 μM.
  • 体内研究

    BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
    BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.

    Animal Model: Male and female SMN2 +/+ , SMN2Δ7 +/+ , Smn +/– mice
    Dosage: 75 mg/kg
    Administration: Intraperitoneal injection; daily; from postnatal day 0 to 21
    Result: Caused a modest extension in the median survival of SMA KO animals by two days.
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione上下游产品信息
上游原料
下游产品
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 试剂级价格
  • 更新日期：2024/04/30
  • 产品编号：HY-111055
  • 产品名称：3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione BIP-135
  • CAS编号：941575-71-9
  • 包装：1mg
  • 价格：681元
  • 更新日期：2024/04/30
  • 产品编号：HY-111055
  • 产品名称：3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione BIP-135
  • CAS编号：941575-71-9
  • 包装：10mg
  • 价格：2400元
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione生产厂家
  • 公司名称：TORONTO
  • 联系电话：--
  • 电子邮件：info@trc-canada.com
  • 国家：加拿大
  • 产品数：6088
  • 优势度：71
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