ChemicalBook CAS数据库列表 (Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮

(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮

CAS号:1420071-30-2
英文名:1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
中文名:(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮
CBNumber:CB42667852
分子式:C22H12BrN3O4S
分子量:494.32
MOL File:1420071-30-2.mol

(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮化学性质

安全信息

(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮性质、用途与生产工艺

生物活性 Bioymifi 是一种有效的 TRAIL 受体 DR5 激活剂，与DR5的胞外结构域 (ECD) 结合，Kd 为 1.2 μM，Bioymifi 可作为单一的诱导剂诱导 DR5 的聚集，导致细胞凋亡。
体外研究

Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.
Bioymifi induces apoptosis via death receptor DR5. Bioymifi promotes DR5 aggregation and activation. Bioymifi shares the same DR5-dependent extrinsic apoptotic pathway with TRAIL. Binding of bioymifi to DR5 recruits FADD, which in turn engages with the apical caspase-8 to form death-inducing signaling complex (DISC) Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.

(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮上下游产品信息

上游原料

下游产品

(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮生产厂家