ChemicalBook CAS数据库列表 GRI977143; GRI-977143
GRI977143; GRI-977143
- CAS号:325850-81-5
- 英文名:2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
- 中文名:GRI977143; GRI-977143
- CBNumber:CB42652142
- 分子式:C22H17NO4S
- 分子量:391.44
- MOL File:325850-81-5.mol
GRI977143; GRI-977143化学性质
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble10mg/mL, clear
- 形态 :powder
- 颜色 :white to light brown
安全信息
- 危险品标志 :Xn,N
- 危险类别码 :22-43-50/53
- 安全说明 :36/37-60-61
- 危险品运输编号 :UN 3077 9 / PGIII
- WGK Germany :3
GRI977143; GRI-977143性质、用途与生产工艺
- 生物活性 GRI977143 是特异性的 LPA2 受体的激动剂，其EC50 值为3.3 μM。
-
靶点
LPA 2 Receptor
3.3 μM (EC 50 )
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体外研究
GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6.
Cell Proliferation Assay
Cell Line: Vector- and LPA2-transduced MEF cells (2 × 10 4 ) [1] . Concentration: 10 μM. Incubation Time: 24-72 h. Result: Did not cause a significant increase in vector cell proliferation except at 72 h (p < 0.05). Apoptosis Analysis.
Cell Line: Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. Concentration: 10 μM. Incubation Time: 24 h. Result: Reduced caspase 3 and 7 activation on LPA2-transduced MEF cells by 51 ± 3% and was approximately as potent as 3 μM LPA or OTP.
Protected against doxorubicin-induced apoptosis by inhibiting caspase 3, 7, 8, and 9 and reducing DNA fragmentation.
GRI977143; GRI-977143上下游产品信息
上游原料
下游产品
GRI977143; GRI-977143 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-100676
- 产品名称：GRI977143; GRI-977143 GRI977143
- CAS编号：
- 包装：5 mg
- 价格：1300元
- 更新日期：2024/11/08
- 产品编号：HY-100676
- 产品名称：GRI977143; GRI-977143 GRI977143
- CAS编号：
- 包装：10 mg
- 价格：2200元
GRI977143; GRI-977143生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
