BMS-3
- CAS号:1338247-30-5
- 英文名:N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)cyclopropanecarboxaMide
- 中文名:BMS-3
- CBNumber:CB42598622
- 分子式:C17H12Cl2F2N4OS
- 分子量:429.27
- MOL File:1338247-30-5.mol
- 密度 :1.69±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMF: 15 mg/ml; DMSO: 25mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.2 mg/ml; Ethanol: 1 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :8.28±0.70(Predicted)
- 颜色 :White to off-white
BMS-3性质、用途与生产工艺
- 生物活性 BMS-3 是一种高效的 LIMK 抑制剂,抑制 LIMK1 和 LIMK2,IC50 分别为 5 nM 和 6 nM。
-
靶点
LIMK1
5 nM (IC 50 )
LIMK2
6 nM (IC 50 )
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体外研究
BMS-3 (Compound 2) causes a dose-dependent reduction in cell count and induces mitotic arrest by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment in A549 human lung cancer cells. BMS-3 inhibits A549 human lung cancer cells with EC 50 value of 154 nM. BMS-3 is used to demonstrate the direct participation of LIMK1 in the phosphorylation of Cofilin. Inhibition of p-LIMK with 1-50 μM of BMS-3 results in a dose-dependent decrease of p-Cofilin after 10 min incubation in capacitating conditions. As a control, sperm are also incubated for 10 min under non-capacitating conditions which result in low levels of p-Cofilin. In the presence of 1 or 50 μM of BMS-3, actin polymerization levels are significantly lower compared to controls (DMSO). Mouse sperm are incubated under capacitating conditions for 90 min in the presence or absence of increasing concentrations of p-LIMK inhibitor BMS-3 (0, 1, 10 and 50 μM). The increasing concentrations of BMS-3 result in a strong decrease on the percentage of sperm that undergoes acrosomal exocytosis after stimulation with 20 μM of Progesterone.
- 更新日期:2023/01/06
- 产品编号:S3525
- 产品名称:BMS-3 BMS-3
- CAS编号:1338247-30-5
- 包装:25mg
- 价格:5872.98元
- 更新日期:2021/03/30
- 产品编号:S3525
- 产品名称:BMS-3 BMS-3
- CAS编号:1338247-30-5
- 包装:5mg
- 价格:1957.98元
- 公司名称:Novachemistry
- 联系电话:44-20819178-90 02081917890
- 电子邮件:info@novachemistry.com
- 国家:英国
- 产品数:4381
- 优势度:58