ChemicalBook CAS数据库列表 7(R)-Maresin 1
7(R)-Maresin 1
- CAS号:1268720-28-0
- 英文名:7(R)-Maresin 1
- 中文名:7(R)-Maresin 1
- CBNumber:CB42590080
- 分子式:C22H32O4
- 分子量:360.49
- MOL File:1268720-28-0.mol
7(R)-Maresin 1化学性质
- 沸点 :559.4±50.0 °C(Predicted)
- 密度 :1.048±0.06 g/cm3(Predicted)
- 储存条件 :Store at -80°C, protect from light
- 溶解度 :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
- 形态 :Liquid
- 酸度系数(pKa) :4.58±0.10(Predicted)
- 颜色 :Colorless to light yellow
7(R)-Maresin 1性质、用途与生产工艺
- 生物活性 Maresin 1 是人体内源性的 DHA 产生的 特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。
-
体外研究
Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production.
Cell Viability Assay
Cell Line: Neutrophils (2 ╳10 5 cells/well). Concentration: 300 nM. Incubation Time: 30 min. Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well [3] . -
体内研究
Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC 50 =0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice.
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis.
Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS). Dosage: 0.1, 0.3, and 1 μg/animal. Administration: Intraocular route once a day from day 0 to day 7. Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
7(R)-Maresin 1上下游产品信息
上游原料
下游产品
7(R)-Maresin 1 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-116429
- 产品名称：Maresin 1
- CAS编号：
- 包装：10 μg (277.4 μM * 100 μL in Ethanol)
- 价格：2500元
- 更新日期：2024/11/08
- 产品编号：HY-116429
- 产品名称：7(R)-Maresin 1 Maresin 1
- CAS编号：1268720-28-0
- 包装：25μg(277.4μM * 250μL in Ethanol)
- 价格：5000元
7(R)-Maresin 1生产厂家
- 公司名称：CAYMAN
- 联系电话：--
- 电子邮件：cayman@caymanchem.com
- 国家：美国
- 产品数：6213
- 优势度：81
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
