7(R)-Maresin 1

生物活性体外研究体内研究 7(R)-Maresin 1 试剂级价格

7(R)-Maresin 1

CAS号:1268720-28-0
英文名:7(R)-Maresin 1
中文名:7(R)-Maresin 1
CBNumber:CB42590080
分子式:C22H32O4
分子量:360.49
MOL File:1268720-28-0.mol

7(R)-Maresin 1化学性质

沸点 :559.4±50.0 °C(Predicted)
密度 :1.048±0.06 g/cm3(Predicted)
储存条件 :Store at -80°C, protect from light
溶解度 :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
形态 :Liquid
酸度系数(pKa) :4.58±0.10(Predicted)
颜色 :Colorless to light yellow

7(R)-Maresin 1性质、用途与生产工艺

生物活性 Maresin 1 是人体内源性的 DHA 产生的特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。

体外研究

Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production.

Cell Viability Assay

Cell Line:	Neutrophils (2 ╳10 ⁵ cells/well).
Concentration:	300 nM.
Incubation Time:	30 min.
Result:	Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well ^[3] .

体内研究

Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC ₅₀ =0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice.
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis.

Animal Model:	Male CD1 mice (8-10 wk of age) (colitis was induced by DSS).
Dosage:	0.1, 0.3, and 1 μg/animal.
Administration:	Intraocular route once a day from day 0 to day 7.
Result:	MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.