2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑
![2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑,40045-50-9,结构式](https://www.chemicalbook.com/CAS/GIF/40045-50-9.gif)
- CAS号:40045-50-9
- 英文名:5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
- 中文名:2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑
- CBNumber:CB42518901
- 分子式:C5H3N5O2S3
- 分子量:261.3
- MOL File:40045-50-9.mol
- 熔点 :160 °C(dec.)
- 沸点 :549.8±42.0 °C(Predicted)
- 密度 :1.88±0.1 g/cm3(Predicted)
- 储存条件 :Store at RT
- 溶解度 :DMSO : 62.5 mg/mL (239.19 mM; Need ultrasonic)
- 形态 :Pale yellow solid
- 酸度系数(pKa) :0.65±0.10(Predicted)
- 颜色 :Light yellow to Amber to Dark green
- InChI :InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8)
- InChIKey :NQQBNZBOOHHVQP-UHFFFAOYSA-N
- SMILES :S1C(SC2=NC=C([N+]([O-])=O)S2)=NN=C1N
- 海关编码 :2934100090
2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑性质、用途与生产工艺
- 生物活性 SU3327 是一种有效的，选择性的且具有底物竞争性的 JNK 抑制剂，IC50 为 0.7 μM。SU3327 还以 IC50 值为 239 nM 抑制 JNK 和 JIP 之间的蛋白相互作用。SU3327 对 p38α 和 Akt 激酶的活性较低。
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靶点
IC50: 0.7 μM (JNK); 239 nM (JNK-JIP interactions)
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体外研究
SU3327 (compound 9) is able to inhibit TNF-α stimulated phosphorylation of c-Jun in HeLa cells (EC 50 = 6.23 μM).
SU3327 (25 nM) pretreatment of human-derived cerebral microvascular endothelial cells (hCMEC/D3) effectively reduces LPS-induced polymorphonuclear leukocytes (PMN) rolling/adhesion to hCMEC/D3, prevents activation of AP-1, and significantly reduces expression of VCAM-1. -
体内研究
SU3327 (Compound 9; 25 mg/kg; intraperitoneal injection; male BKS.Cg-+Lepr db /+Lepr db /OlaHsd db/db mice) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes.
SU3327 (Compound 9) has favorable microsomal and plasma stability (T 1/2 = 27 min).Animal Model: Male BKS.Cg-+Lepr db /+Lepr db /OlaHsd db/db mice (11-week-old ) injected with insulin Dosage: 25 mg/kg Administration: Intraperitoneal injection Result: Resulted in a statistically significant reduction in blood glucose levels.
- 更新日期：2025/02/08
- 产品编号：HY-107597
- 产品名称：2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑 Halicin
- CAS编号：40045-50-9
- 包装：1 mg
- 价格：300元
- 更新日期：2025/02/08
- 产品编号：HY-107597
- 产品名称：2-氨基-5-[(5-硝基-2-噻唑基)硫代]-1,3,4-噻二唑 SU3327
- CAS编号：40045-50-9
- 包装：5mg
- 价格：750元
- 公司名称：TCI Europe
- 联系电话：320-37350700
- 电子邮件：sales@tcieurope.eu
- 国家：欧洲
- 产品数：23671
- 优势度：75
