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安三烯菌素B

安三烯菌素B,82189-04-6,结构式
安三烯菌素B
  • CAS号:82189-04-6
  • 英文名:mycotrienin II
  • 中文名:安三烯菌素B
  • CBNumber:CB41375521
  • 分子式:C36H50N2O8
  • 分子量:638.79
  • MOL File:82189-04-6.mol
安三烯菌素B化学性质
  • 储存条件 :-20°C
  • 溶解度 :Soluble in DMSO, DMF, Ethanol or Methanol
  • 形态 :solid
  • 颜色 :Pale-yellow
  • 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.

安三烯菌素B性质、用途与生产工艺

  • 生物活性 Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性,但对细菌无活性。Ansatrienin B 具有抗肿瘤活性,可作为 ADC 毒素分子。
  • 体外研究

    Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively. Ansatrienin B inhibits the release of 45 calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC 50 ) value of 21 nM.Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC 50 =58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC 50 of 300 nM.

  • 体内研究

    Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD 50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice.

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安三烯菌素B生产厂家
  • 公司名称:Novachemistry
  • 联系电话:44-20819178-90 02081917890
  • 电子邮件:info@novachemistry.com
  • 国家:英国
  • 产品数:4381
  • 优势度:58
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